Postmortem imaging can help here too.įigure 3. While research has made progress to determine hippocampal subfield functions in humans ( Krekelberg et al., 2006 Bakker et al., 2008 Yassa et al., 2010 Yassa and Stark, 2011), the neuroimaging field craves hippocampal subfield maps that stem from ground truth anatomy. This topic has been reviewed by Yassa and Stark (2011). Studies suggest that CA3 plays a role in pattern completion (triggers recall using clues from the encoding event) and pattern separation (matches old stored information with incoming new information), especially for spatial information Kesner et al., 2004 Knierim et al., 2006 Acsady and Kali, 2007 Kesner, 2007b). Several lines of evidence suggest that the function of the dentate gyrus is pattern separation, which emphasizes the differences between old and new memories ( Kesner et al., 2004 Kesner, 2007a Rolls, 2010 Palmer and Good, 2011 Schmidt et al., 2012). Subregion (corresponding color): parasubiculum (yellow) presubiculum (purple) subiculum (blue) CA1 (red) CA2/3 (green) hippocampal-amygdala transition area (light green) molecular layer hippocampus and dentate gyrus (rust/dark brown) dentate gyrus (pale blue) CA4/hilus (light brown). Note the comprehensive number of subregions labeled. Selected anterior to posterior slices of the human hippocampus, segmented with FreeSurfer (v.6), based on ex vivo MRI contrast and modeled from manual labels. Atlas of the hippocampal subregions modeled from ex vivo magnetic resonance imaging.
0 kommentar(er)
